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KMID : 0352720050290020086
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Journal of Ginseng Research
2005 Volume.29 No. 2 p.86 ~ p.93
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Inhibitory Action of the Ginseng Total Saponin on the Nalbuphine-Induced Tolerance and Withdrawal Syndrome
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Kim DH
Yoo HS/Jang CG/Kang JS/Kim DS/Choi KH/Jang SY/Oh SW
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Abstract
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This study was undertaken to determine the antagonism of the ginseng total saponin (GTS) on the development of nalbuphine-induced tolerance and physical dependence. GTS is known to have antinarcotic action with a dose of 100㎎/kg (i.p.) in rats. GTS significantly inhibits the development of nalbuphine-induced physical dependence as well as the tolerance. The level of pCRES was elevated in the striatum by the chronic treatment with nalbuphine or GTS, however, the elevation of pCRES was inhibited by the GTS co-treatment. It has been suggested that NMDA receptor and/or NO is involved in the penomena of opioid dependence and withdrawal. However, the level of nNOS and NRI was not modulated by the treatment with nalbuphine or GIS on the cortex, hippocampus and striatum in the rat brain. These results suggest that the GTS could be used to ameliorate the nalbuphine tolerance and withdrawal symptoms.
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